Wednesday, 13 July 2011

ANTINEOPLASTIC AGENTS / ANTICANCER DRUGS

INTRODUCTION OF ANTINEOPLASTIC AGENTS / ANTICANCER DRUGS:

Antineoplastics or Anticancer drugs are the drugs that prevent or inhibit the maturation and proliferation of neoplasms. 

Antineoplastic agents travel the body and destroy cancer cells. Many of the side effects associated with antineoplastic agents occur because treatment destroys the body's normal cells in addition to cancerous cells.

General Toxicities of Antineoplastic / Anticancer Drugs are:
  • Bone marrow depression
  • Lymphocytopenia
  • GIT Stomatitis
  • Diarrhoea
  • Nausea and Vomiting
  • Alopecia
  • Hyperuricaemia
  • Hair loss
Antineoplastic drugs / Anticancer Drugs are not only used prominently in different types of cancers but also in conjunction with surgery, radiotherapy and immunotherapy in the combined modality approach for many solid tumors, especially metastatic. 

Types of Cancer


Types of CancerAffected Area
Anal cancerAnus
Breast CancerBreast
Bladder CancerUrinary Bladder
Bone marrow CancerShafts of long bones
Colon CancerColon
Cervical CancerCervix
Eye CancerEye
Gynecological CancerFemale Reproductive organs
Lung CancerLung
Osteo sarcomametaphyseal region of tubular long bones
Wilms tumourKidney
LeukemiaBlood
Larynx CancerLarynx
Testicular cancerTestis
Rectal CancerRectum

Classification of Antineoplastic Agents / Anticancer Drugs 2
  1. Alkylating Agents
    • Nitrogen mustards: Melphalan, Cyclophosphamide, Ifosfamide
    • Nitrosoureas
    • Alkylsulfonates
    • Ethyleneimines
    • Triazene
    • Methyl Hydrazines
    • Platinum Coordination complexes: Cisplatin, Carboplatin, Oxaliplatin
  2. Antimetabolites
    • Folate Antagonists: Methotrexate
    • Purine antagonists
    • Pyrimidine antagonists: 5-Fluorouracil, Cytarabibe
  3. Natural Products
    1. Plant Products
      • Vinca Alkaloids: Vincristine, Vinblastine
      • Taxanes: Paclitaxel, Docetaxel
      • Epipodophyllotoxins: Etoposide
      • Camptothecins: Irinotecan
    2. Microorganism Products
      • Antibiotics: Doxorubicin, Bleomycin
      • Enzymes: L-Asparaginase
  4. Miscellaneous
    • Hydroxyurea
    • Imatinib Mesylate
    • Rituximab
    • Epirubicin
    • Bortezomib
    • Zoledronic Acid
    • Geftinib
    • Leucovorin
    • Pamidronate
    • Gemcitabine
  5. Hormones and Antagonists
    • Corticosteroids: Prednisone, Dexamethasone
    • Estrogens: Ethinyloestradiol
    • Antiestrogens: Tamoxifen
    • Progesteron derivative: Megestrol Acetate
    • Androgen: Testosterone propionate
    • Antiandrogen: Flutamide , Bicalutamide
    • Aromatase inhibitor: Letrozole , Anastrazole
    • 5-alpha reductase inhibitor: Finasteride
    • GnRH Analogue: Leuprolide, Buserelin
    • Growth Hormone, glucagon and insulin inhibitor: Octreotide

SRS Antineoplastic Products / Anticancer Drugs:


Sr. No.Product (INJECTION)Spec.StrengthsPack Size
1Cyclophosphamide InjectionBP,USP200mg, 500mg, 1gm1 vial
2Methotrexate InjectionBP25mg1 vial
3Fluorouracil InjectrionBP50mg1x5 amp
4Cisplatin InjectionBP1mg1 vial
5Doxorubicin Hydrochloride InjectionBP,USP2mg1 vial
6Doxorubicin Hydrochloride for InjectionBP,USP2mg1 vial
7Irinotecan Hydrochloride InjectionIP20mg1 vial
8Carboplatin InjectionBP10mg1 vial
9Vincristine Sulfate InjectionUSP1mg1 vial
10Gemcitabine for InjectionUSP200mg, 1gm1 vial
11Bleomycin for InjectionUSP15 units1 vial
12Paclitaxel InjectionUSP30mg,100mg,260m1 vial
13Epirubicin Hydrochloride for InjectionInhouse10mg, 50mg, 100mg1 vial
14Etoposide InjectionUSP20mg1 vial
15Docetaxel Injection ConcentrateInhouse20mg,80mg,120mg1 vial
16Solvent for Docetaxel Injection ConcentrateInhouse1.5ml, 3ml, 6ml, 9ml1 vial
17Pegylated Doxorubicin HCl liposome InjectionInhouse10ml,1 vial
18Zoledronic Acid for InjectionInhouse4mg1 vial
19Vinblastine Sulphate for InjectionBP10mg1 vial
20Oxaliplatin InjectionInhouse1 vial
21L-Asparaginase for InjectionInhouse5000 IU, 10000 IU1 vial
22Fludarabine Phosphate for InjectionUSP50mg1 vial
23Octreotide InjectionInhouse50mcg, 100mcg1 amp



Sr. No.Product (TABLETS)Spec.StrengthsPack Size (Strip)
1Tamoxifen Citrate TabletsBP,USP10mg, 20mg10's
3Methotrexate TabletsBP2.5mg, 5.0mg, 7.5mg10's
5Bicalutamide TabletsUSP50mg10's
6Anastrozole TabletsInhouse1mg10's
7Letrozole TabletsUSP2.5mg10's
8Gefitinib TabletsInhouse250mg10's
9Fludarabine Phosphate TabletsInhouse10mg10's
11Flutamide TabletsInhouse250mg10's



Sr. No.Product (CAPSULES)Spec.StrengthsPack Size
1Hydroxyurea CapsulesUSP500mg10's strip
2Imatinib CapsulesInhouse100mg, 400mg10's jar
3Temozolomide CapsulesInhouse20mg, 100mg, 250mg5's jar
4Etoposide CapsulesIP,USP50mg, 100mg4's, 8's jar
Posted by SRIKANTH at 21:48

No comments:

Post a Comment

Subscribe to: Post Comments (Atom)